What Is Keratin and What Is Its Purpose

Keratin is a fibrous structural protein found in animal cells and used to form specialized tissues. Specifically, the proteins are only produced by chordates (vertebrates, Amphioxus, and urochordates), which includes mammals, birds, fish, reptiles, and amphibians. The tough protein protects epithelial cells and strengthens certain organs. The only other biological material possessing similar toughness is the protein chitin, found in invertebrates (e.g., crabs, cockroaches). There are different forms of keratin, such as ÃŽ ±-keratins and harder ÃŽ ²-keratins. Keratins are considered examples of scleroproteins or albuminoids. The protein is rich in sulfur and insoluble in water. The high sulfur content is attributed to the richness of the amino acid cysteine. Disulfide bridges add strength to the protein and contribute to insolubility. Keratin is not typically digested in the gastrointestinal tract. Keratin Word Origin The word keratin comes from the Greek word keras which means horn. Examples of Keratin Bundles of keratin monomers form what are called intermediate filaments. Keratin filaments may be found in the cornified layer of the skins epidermis in cells called keratinocytes. The  ÃŽ ±-keratins include: hairwoolnailshoovesclawshorns   Examples of  ÃŽ ²-keratins include: scales of reptilesreptile nailsbird clawstortoise shellsfeathersporcupine quillsbird beaks The baleen plates of whales also consist of keratin. Silk and Keratin Some scientists classify the silk fibroins that are produced by spiders and insects as keratins, although there are differences between the phylogeny of the materials, even if their molecular structure is comparable. Keratin and Disease While animal digestive systems arent equipped to deal with keratin, certain infectious fungi feed on the protein. Examples include the ringworm and athletes foot fungus. Mutations in the keratin gene can produce diseases, including epidermolytic hyperkeratosis and keratosis pharyngis. Because keratin is not dissolved by digestive acids, ingesting it causes problems in people who eat hair (tricophagia) and results in vomiting of hairballs in cats, once enough hair has accumulated from grooming. Unlike felines, humans dont vomit hairballs, so a large accumulation of hair in the human digestive tract can cause the rare but fatal intestinal blockage called Rapunzel syndrome.